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FU Berlin
Digitale Dissertation

Tido Labsch :
Qualitative and quantitative morphological studies on hearts in prenatal and juvenile kittens
Qualitative und quantitative morphologische Untersuchungen an Herzen pränataler und juveniler Katzen

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Abstract

In this study we examined the development of selected parameters of the hearts of 109 kittens (strain: European Short Hair), age: up to 43 days. Apart from this we also took into account the histological sections of the Ductus arteriosus Botalli of some of the animals (light microscopically) to assess the quality of the obliterational process.
On the basis of the measured results we proposed standardized factors and regression formulas for the cats of this strain and age for the parameters body weight, body length, absolute and relative heart weight, thickness of the ventricular walls, and nuclear volume of the cardiomyocytes. Body weight, body length, absolute heart weight, and the thickness of the free left ventricular wall show a linear age development. The thickness of the free right ventricular wall decreases up to the age of 20 days and increases thereafter. The intramyocardial connective tissue increases with growing age. The volumes of the cardiomyocytes and the thickness of the free right ventricular wall show a parabolic development. In the free left ventricular wall the lowest point of this parabola is reached after 11 days and in the free right ventricular wall after 21 days. No sexual dimorphism could be noticed, but the development of the body weight of the male animals showed a higher increase. On the basis of the thickness of the ventricular walls a modified arterial pressure index was established. Mitotic activities of the cardiomyocytes occurred within a postnatal period of 30 days. An increase of the occurrence of polyploid cardiomyocyte nuclei in the cats heart muscle is assumed. The Ductus arteriosus Botalli in cats showed its complete anatomical closure on the 10th day of life; the physiological closure is assumed to occur directly after birth. The closing process is marked by a gradual intimal thickening which obliterates the lumen. This development is accompanied by a migration of numerous myofibroblasts from the media into the intima.

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More Information:

Online available: http://www.diss.fu-berlin.de/1999/98/indexe.html
Language of PhDThesis: german
Keywords: cats; heart; ductus arteriosus; myocardium; mitosis; collagen; nuclei
DNB-Sachgruppe: 34 Veterinärmedizin
Date of disputation: 27-Sep-1999
PhDThesis from: Fachbereich Veterinärmedizin, Freie Universität Berlin
First Referee: Univ.-Prof. Dr. R. Berg
Second Referee: Univ.-Prof. Dr. H. Tönhardt
Third Referee: Univ.-Prof. Dr. L. Brunnberg
Contact (Advisor): tido@lycosmail.com
Date created:14-Dec-2000
Date available:06-Feb-2001

 

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