DARWIN Digitale Dissertationen German Version Strich

FU Berlin
Digitale Dissertation

Gerald Mende :
Effect of simple manipulations on the concentration of prolactin and corticosterone in laboratory rats
Untersuchung zur Beurteilung der Belastung von Laborratten durch einfache Manipulationen, an den Parametern Kortikosteron und Prolaktin

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Abstract

The aim of this investigation was to determine the degree of stress experienced by laboratory rats when subjected to defined manipulations such as: "weighing", "transportation", "fixation using neck restraint", "fixation using a towel", "i. m. injection", "oral administration" and marking by means of "earperforation" or "microchip implantation". Induced stress was evaluated by the production of prolactin and corticosterone in male Wistar rats.
The results show that all the manipulations carried out gave rise to stress responses in the animals. However a differentiated assessment of the various manipulations, i.e. analysis of the blood samples taken by puncture of the retrobulbar plexus vein under CO2 anaesthetic, did not confirm this. There was no significant difference between the hormone values resulting from individual manipulations whereby all the values were higher than would be the case for a CO2 anaesthetic alone.

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More Information:

Online available: http://www.diss.fu-berlin.de/1999/101/indexe.html
Language of PhDThesis: german
Keywords: rats; stress; manipulations; prolactin; corticosterone
DNB-Sachgruppe: 34 Veterinärmedizin
Date of disputation: 16-Dec-1999
PhDThesis from: Fachbereich Veterinärmedizin, Freie Universität Berlin
First Referee: Prof. Dr. N.-C. Juhr
Second Referee: Prof. Dr. W. Scharmann
Third Referee: Prof. Dr. H. Tönhardt
Contact (Author): Gerald.Mende@uni-konstanz.de
Contact (Advisor): gmende@zedat.fu-berlin.de
Date created:14-Dec-2000
Date available:06-Feb-2001

 

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