DARWIN Digitale Dissertationen German Version Strich

FU Berlin
Digitale Dissertation

Karsten Holland :
The influence of endurance training on the female hemostatic system under consideration of Vascular Endothelial Growth Factor (VEGF)
Der Einfluß einer körperlichen Ausdauerleistung auf das hämostatische System bei Frauen unter besonderer Berücksichtigung des Vascular Endothelial Growth Factors (VEGF)

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Abstract

The present study deals with the influence of endurance exercise on the hemostatic system under consideration of the vascular endothelial growth factor. A total of 28 female athletes participated in the study. This included 12 athletes practising a triathlon (1.5 km swimming, 40 km cycling, 10 km running) and 16 performing a marathon (42.195 km running). The 16 healthy trained marathon runners were studied prior to, immediately after and 24h after the 1999 Berlin Marathon. The 12 triathletes were studied prior to and immediately after the endurance exercise. The coagulation parameters Thromboplastin Time, Prothrombin Time (aPTT), Factor VIII, Factor XII, Fibrinogen, Fibrinmonomers (FM) and von Willebrand Factor (vWF) were determined. The fibrinolytic answer has been determined by the tissue-Plasminogen Activator (t-PA), Plasminogen Activator Inhibitor (PAI) and D-Dimers concentration. The values were corrected for hemoconcentration. Results showed marked and partially long-lasting changes. The coagulation system was markedly activated and was partially long-lasting (aPTT¯, FVIII­, vWF­, FXII­, FM­). Simultaneously the fibrinolytic activity increased (t-PA­) but not as long as the coagulation system. In female athletes an aerobe endurance exercise leads in contrast to male athletes not to a measurable change of the D-Dimer concentration. It was concluded that a marathon as well as a triathlon did not alter the VEGF concentration. Further investigations concerning production, release, binding and elimination of VEGF are required.

Table of Contents

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Titelbatt und Inhaltsverzeichnis
A. Einleitung 7
1. Thematik und Fragestellung 7
2. Physiologie des hämostatischen Systems 8
3. Endothelfunktion 15
4. Vascular endothelial growth factor (VEGF) 16
B. Methodik 18
1. Experimentelle Durchführung 18
2. Untersuchungen zum Blutgerinnungssystem 24
3. Untersuchungen zum Fibrinolysesystem 28
4. Weitere durchgeführte Untersuchungen 31
5. Bestimmung der relativen Plasmavolumenveränderung 32
6. Zuverlässigkeit der angewendeten Labormethoden 33
7. Statistische Auswertung 35
C. Ergebnisse 40
1. Einfluß der Hämokonzentration auf die Ergebnisse 40
2. Halle Triathlon 40
3. Berlin Marathon 48
4. Zusammenfassung der Ergebnisse 56
D. Diskussion 58
1. Verhalten des Gerinnungssystems bei körperlicher Ausdauerleistung 58
2. Körperliches Ausdauertraining und Gerinnung 62
3. Verhalten des fibrinolytischen Systems bei körperlicher Ausdauerleistung 63
4. Körperliches Ausdauertraining und Fibrinolyse 69
5. Verhalten des VEGF bei körperlicher Ausdauerleistung 70
6. Einfluß einer Ausdauerleistung auf VEGF 71
7. Geschlechtsspezifische Unterschiede 72
E. Zusammenfassung 74
F. Literaturverzeichnis 76
G. Anhang 92
H. Danksagung 106

More Information:

Online available: http://www.diss.fu-berlin.de/2002/141/indexe.html
Language of PhDThesis: german
Keywords: exercise, hemostasis, fibrinolysis, VEGF
DNB-Sachgruppe: 33 Medizin
Date of disputation: 09-Jul-2002
PhDThesis from: Fachbereich Humanmedizin, Freie Universität Berlin
First Referee: PD Dr. med. Hanns-Christian Gunga
Second Referee: Prof. Dr. med. Dieter Böning
Contact (Author): karsten.holland@web.de
Date created:02-Aug-2002
Date available:10-Sep-2002

 

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