DARWIN Digitale Dissertationen German Version Strich

FU Berlin
Digitale Dissertation

Jörg Pelz :
Laser-induced-thermotherapie i(LITT) in the treatment of liver tumors - Combined therapy with variations of vessels occlusion of the liver
Die Laserinduzierte Thermotherapie (LITT) zur Behandlung von Lebermetastasen - Kombinationstherapie mit Varianten der selektiven/passageren Gefäßokklusion der Leber

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Abstract

OBJECTIVE: To assess the effect of combined laser-induced thermotherapy (LITT) and hepatic blood flow manipulation (DSM) on tumor response and intrahepatic temperature distribution in rats with liver tumors. SUMMARY BACKGROUND DATA: Laser-induced thermotherapy is a promising in situ ablation technique for malignant liver tumors. However, clinical use is still limited, mainly because of the small size of the inducible coagulation necroses. This results in insufficient tumor destruction. METHODS: Colon carcinoma CC531 was implanted in 60 WAG rat livers. Fourteen days later treatment was performed. Tumors were exposed to 1064 nm Nd:YAG laser light at 2 watts for 10 minutes from a diffuser tip applicator placed in the tumor. The animals were randomized into two control (group I: sham-operated, group II DSM only) and five test groups. Group II received DSM alone, group III received LITT alone, group IV received DSM + LITT, group V received LITT and pringle maneuver, group VI received LITT and arterial occlusion and group VII received LITT and venous occlusion. Tumor control was examined 1, 7, and 14 days after treatment. RESULTS: A complete tumor remission was achieved in all rats treated with LITT + DSM (group IV). In contrast, tumor progression was seen in animals treated with LITT alone (group III) or DSM alone (group II), as well as in the sham-operated controls (group I). CONCLUSIONS: The authors' results suggest that the combination of LITT and DSM considerably increases the efficacy of LITT in the treatment of liver metastases in the rat.

Table of Contents

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1. Titelblatt, Inh.-Verzeichnis und Abstract
2. Einleitung
3. Material und Methode
4. Ergebnisse
5. Diskussion
6. Zusammenfassung
7. Literaturliste
8. Materialliste
9. Anhang

More Information:

Online available: http://www.diss.fu-berlin.de/2002/236/indexe.html
Language of PhDThesis: german
Keywords: laser induced thermotherapy, liver tumors
DNB-Sachgruppe: 33 Medizin
Date of disputation: 13-Dec-2002
PhDThesis from: Fachbereich Humanmedizin, Freie Universität Berlin
First Referee: Prof. Dr. med. Christoph-Thomas Germer
Second Referee: Prof. Dr. ing. Prof. h.c. Dr. h.c. Gerhard Müller
Contact (Author): joerg.pelz@web.de
Contact (Advisor): germer@ukbf.fu-berlin.de
Date created:09-Nov-2002
Date available:13-Nov-2002

 

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