DARWIN Digitale Dissertationen German Version Strich

FU Berlin
Digitale Dissertation

Jeannette Aryee-Boi :
Shower-PUVA : an innovative method for local PUVA therapy. Clinical and pharmacokinetic results with psoriasis vulgaris
Dusch-PUVA : Ein innovatives Verfahren der lokalen PUVA-Therapie Klinische und pharmakokinetische Ergebnisse bei Psoriasis vulgaris

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|Abstract| |Table of Contents| |More Information|

Abstract

The shower PUVA therapy is an innovative form of local PUVA therapy, using trioxalen shower (0,27 mg/l) for 5 minutes, followed by long wave ultraviolet light (UVA) irradiation. The purpose of the present work is the evaluation of the therapeutic effectiveness of shower PUVA in the treatment of psoriasis vulgaris. Here we performed a randomized prospective study with fifty psoriasis vulgaris patients. Shower PUVA (n=27) was compared with the so called Berlin regime (n=23). The Berlin regime is a well known psoriasis treatment, consisting of selective UVB phototherapy in combination with the local treatment liquor carbonis detergens in the evening and anthralin in the morning. The results obtained showed a comparable therapeutic effect for shower PUVA therapy and Berlin regime. Additionally the patients treated with Shower PUVA showed a better compliance and needed a shorter hospitalisation period. Furthermore patients with guttate psoriasis responded better to Shower PUVA than to the Berlin regime. Finally we could detect notable concentrations of trioxalen in the psoriatic scales measured by high performance liquid chromatography. Shower PUVA therapy is an innovative, effective method in the treatment of psoriasis vulgaris and it may represent in the future a suitable therapy option for other dermatoses. The good response to shower PUVA therapy can be explained by the proven penetration of trioxalen into the skin, where UVA irradiation leeds to the formation of photoadducts of trioxalen with DNA and subsequent DNA damage, resulting in an antiproliferative effect.

Table of Contents

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TITELBLATT
1. EINLEITUNG
1
1.1. Psoriasis vulgaris 1
1.2. Biologische Wirkung des Lichtes 11
1.3. Psoralene  14
1.4. Untersuchungsgegenstand  41
2. PATIENTEN, MATERIAL UND METHODEN  43
2.1. Klinische Studie: Dusch-PUVA vs. Berliner Schema bei Psoriasis vulgaris  43
2.2. Experimentelle Studie: Nachweis von TMP in psoriatischen Hautschuppen 50 49
3. ERGEBNISSE 51
3.1. Dusch-PUVA vs. Berliner Schema  51
3.2. TMP-Nachweis in psoriatischen Hautschuppen  59
4. DISKUSSION 62
4.1. Phototherapie bei Psoriasis vulgaris  62
4.2. Dusch-PUVA bei Psoriasis vulgaris  63
4.3. Nachweis von TMP in psoriatischen Hautschuppen  67
4.4.  Kanzerogenität von UV-Licht und Photo(chemo)therapie  68
5. ZUSAMMENFASSUNG  71
6. LITERATURVERZEICHNIS  72
ABKÜRZUNGSVERZEICHNIS  93
DANKSAGUNG  95
LEBENSLAUF  96

 
 

More Information:

Online available: http://www.diss.fu-berlin.de/2002/83/indexe.html
Language of PhDThesis: german
Keywords: psoriasis vulgaris, photochemotherapy, PUVA, trioxalen, shower PUVA
DNB-Sachgruppe: 33 Medizin
Date of disputation: 17-May-2002
PhDThesis from: Fachbereich Humanmedizin, Freie Universität Berlin
First Referee: Priv.-Doz. Dr. Beate Tebbe
Second Referee: Prof. Dr. Hans Meffert
Contact (Author): jaryee@yahoo.de
Date created:14-May-2002
Date available:16-May-2002

 

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